Tyris oDNA™ or “optimized DNA” is an unprecedented linear closed DNA format

oDNA™  is a pioneering synthetic double stranded linear closed DNA made of the transgene, surrounded by proprietary loops called “adaptors”. 

Proprietary oDNA™

Our adaptors are made of both natural and non-natural nucleotides, it can be uniquely optimized on a project basis for achieving an unprecedented modulation and enhancement of desired transgene properties. 

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Our oDNATM are only made of the transgene (e.g. gene of interest, promoter, enhancer) sequences

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If required, other key sequences  (e.g. ITRs) can be integrated along with our proprietary adaptors

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Additionally, oDNA™ are free of antibiotic resistance and any bacterial sequences.  

Defining the future

We have developed a library of oDNA™ adaptors and are constantly enriching it to enhance different properties (i.e. including persistence, nuclear translocation, etc.) together with exploring diverse functional response on various organ representative cell types.

Our oDNA™ can be specifically delivered to targeted cells using our exclusively partnered innovative non-viral delivery technology or other widespread delivery platforms